The best place to start is Madrid, capital of Spain. The city has an effervescence and style that is shown in a thousand bars and summer terrazas. Not to mention three of the world's finest art museums.
Barcelona, a bustling port city, vibrant and alive, a feeling that causes most visitors fall in love with the place for Gaudí's splendid modernista architecture, the lively promenade of Las Ramblas, La Boqueria market and the designer clubs, and, not least, for Barça - the city's football team.
In the sunny southern part of Spain you will find Andalusia, former cultural and power centre of the Moors. Throughout this region you will see examples of Moorish architecture and arts. The most famous of which are the Alhambra in Granada and the Mesquite in Cordoba.
Then there's Sevilla, home of flamenco and all the clichés of southern Spain; Valencia, the vibrant Levantine city with an arts scene and nightlife; and Bilbao, a new entry on Spain's cultural route, due to Frank Gehry's amazing Guggenheim museum.
Wander through the narrow streets and fortifications of Toledo and Segovia, catching glimpses of old churches and palaces. In Toledo, visit the church that today houses "The Burial of the Count of Orgaz" one of the finest works produced by the Renaissance master "El Greco".
For those of you, who just want to relax, spend some time on the beautiful sun-drenched beaches of the Costa del Sol, the Costa Brava or the Costa de la Luz or in the Islands where you can practise all kind of sports.